Reports of Scientific Advances - The Coriell Institute for Medical Research
Mammary (breast)
cancer in mice is known to be caused by one or more viruses. Some strains of mice are
resistant and others very susceptible to the same virus. Interestingly, even among the
susceptible strains, males and females who remain virgins have few breast
tumors.
Female mice that breed regularly and are thereby exposed to
different hormone levels have a high incidence of mammary cancer. Although no
infectious agent has been isolated from human breast cancer, certain
"fingerprints" of the mouse virus have been seen in human breast cancer cells.
Our vaccination studies in mice ask whether purified human tumors extract will prevent
mammary cancer in mice . . . (and whether) this substance will be useful in early
detection, or even prevention of breast cancer in women.
Twenty percent of all Americans will be over 65. Most of us live
longer today, but aging is often accompanied by painful and debilitating diseases,
including Alzheimers Disease. The National Institute on Aging (NIA) chose IMR to
establish a cell bank and collect tissue from persons of all ages. Cells are grown from
these samples and used to study why and how people age. Living cells from normal
individuals are stored in liquid nitrogen at -316° F. Later, these cells are thawed and
studied to see how the function of cells from young individuals differ from those of older
persons, and the results are compared with data on cells from patients with
Alzheimers Disease . . .